Mark Smith
This article showcases our top picks for the best Massachusetts based Biopharma companies. These startups and companies are taking a variety of approaches to innovating the Biopharma industry, but are all exceptional companies well worth a follow.
We tried to pick companies across the size spectrum from cutting edge startups to established brands.
We selected these startups and companies for exceptional performance in one of these categories:
- Innovation
- Innovative ideas
- Innovative route to market
- Innovative product
- Growth
- Exceptional growth
- Exceptional growth strategy
- Management
- Societal impact
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Top Massachusetts Biopharma Startups
Data sourced from Crunchbase and SemRush.
Ginkgo Bioworks
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Ginkgo Bioworks is a developer of biological engineering products and custom microbes across multiple markets.
CRISPR Therapeutics
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CRISPR Therapeutics is focused on the development of transformative medicines using its proprietary CRISPR/Cas9 gene-editing platform.
nference
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nference.inc, provides an AI based software platform that synthesizes siloed biomedical knowledge for insights and makes it computable.
Stealth BioTherapeutics
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Stealth BioTherapeutics is a clinical-stage biotechnology company focused on the discovery and commercialization of novel therapies.
Axial Therapeutics
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Axial Therapeutics is a clinical stage biopharmaceutical company harnessing the gut-brain axis to develop novel Central Nervous System.
EGenesis
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EGenesis focuses on leveraging genome editing technology to deliver safe and effective human transplantable cells, tissues, and organs.
Elevian
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Elevian develops medicines that restore youthful regenerative capacity with the potential to treat and prevent many age-related diseases.
Gemini Therapeutics
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Gemini Therapeutics focuses on genetically-defined dry age-related macular degeneration (AMD) and associated rare genetic diseases.
Seres Therapeutics
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Seres Therapeutics is a microbiome therapeutics company focused on discovering and developing Ecobiotic therapeutic products.
Alloy Therapeutics
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Alloy Therapeutics is a biotech company that makes medicine by democratizing access to foundational drug discovery platforms and services.
KSQ Therapeutics
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KSQ Therapeutics is using CRISPR technology within a powerful drug discovery engine to enable high-confidence drug development.
Manus Bio
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Manus Bio makes nature accessible and affordable for a growing society.
Infinity Pharmaceuticals
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Infinity Pharmaceuticals engages in the discovery and development of medicines for the treatment of cancer and related conditions.
Cullinan Oncology
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Cullinan Oncology is a developer of an externally sourced cancer therapeutics intended to end a drug program quickly if the early research.
Epizyme
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Epizyme is a biopharmaceutical company focusing on treatments for blood cancer and tumors.
Cyteir Therapeutics
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Cyteir is developing the next generation of synthetic lethal therapies to treat cancer.
Tessera Therapeutics
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Tessera Therapeutics is an early-stage life sciences company.
Kojin Therapeutics
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Kojin is a biopharmaceutical company that develops new targeted therapeutics based on cell state and ferroptosis biology.
AffyImmune Therapeutics
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AffyImmune Therapeutics is a biopharmaceutical company developing genetically engineered immune cells to fight cancer.
Ultivue
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Ultivue is a biotechnology company that specializes in tissue imaging, diagnostics, and multiplexing.
Selecta Biosciences
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Selecta Biosciences is a clinical-stage biotechnology company with an unrelenting commitment to overcoming immunogenicity.
Catamaran Bio
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Catamaran Bio is a biotechnology company that specializes in allogeneic immune cell therapies.
CAMP4 Therapeutics
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CAMP4 Therapeutics is a biotechnology company.
Verastem Oncology
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Verastem is a biopharmaceutical company that focuses on discovering and developing novel drugs that selectively target cancer stem cells.
Arbor Biotechnologies
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Unlocking nature’s biodiversity to create transformative products in human health and sustainability
Foghorn Therapeutics
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Foghorn Therapeutics is developing therapies based on a system that directs which genes our cells express,
Keystone Dental
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Keystone Dental is an oral healthcare company delivering advanced, easy-to-use implants, biomaterials and planning software.
Arrakis Therapeutics
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Arrakis Therapeutics is a biopharmaceutical developing drugs for neurological disorders and other diseases.
OncXerna Therapeutics
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OncXerna Therapeutics offers precision medicine using an innovative RNA-based biomarker platform.
Imara
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Imara is provider of novel therapeutics for the people living with sickle cell disease and hemoglobinopathies.
New Health Sciences
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New Health Sciences develops a technology to extend the shelf life of refrigerated red blood cells using novel storage methods.
Pieris Pharmaceuticals
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Pieris Pharmaceuticals is a clinical-stage biotechnology company applying its proprietary.
Compass Therapeutics, Inc.
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Compass Therapeutics is a biopharmaceutical company that focuses on drugging the immune system to treat human diseases.
Satellite Bio
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Satellite Bio specializes in cell therapy, regenerative medicine, synthetic biology, cell biology, and tissue engineering.
Aileron Therapeutics
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Aileron Therapeutics is a biopharmaceutical company that develops a class of drugs called Stapled Peptides.
HotSpot Therapeutics
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HotSpot Therapeutics is a developer of a therapy platform designed to discover medicines and provide proper treatment.
Rheos Medicines
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A biopharmaceutical company developing novel medicines that modulate metabolic pathways in immune cells to treat disease.
Paratek Pharmaceuticals
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Paratek Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development and commercialization of innovative therapies.
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Navitor Pharma is a developer of novel medicines designed to target specific nutrient-sensing proteins to treat diseases.
IFM Therapeutics
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DescriptionIFM Therapeutics is a pharmaceutical company focused on developing biological treatments for autoimmune diseases.
Chiasma
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Chiasma is a biopharmaceutical company developing oral drugs for the treatment of orphan diseases.
AZTherapies
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AZTherapies is a clinical stage biotech company developing breakthrough treatments for neuroinflammation-related diseases.
Dianthus Therapeutics
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Dianthus Therapeutics is a biotech company operating in stealth mode.
resTORbio
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resTORbio is a clinical-stage biopharmaceutical company focused on the development and commercialization of novel therapeutics.
Atea Pharmaceuticals
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Atea Pharmaceuticals focuses on the discovery and development of next-generation therapeutics for severe human viral infections.
Cue Biopharma
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Cue Biopharma has developed a highly productive platform for the treatment of cancer and autoimmune disease.
Akston Biosciences
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Akston Biosciences Corporation leverages its novel fusion protein platform to develop and manufacture new classes of biologics.
Corvia Medical
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Corvia Medical develops transcatheter device designed to reduce the symptoms or slow the progression of heart failure.
Minerva Neuroscience
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Minerva Neurosciences is a clinical-stage biopharmaceutical company
Bicara Therapeutics
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Bicara Therapeutics is developing a pipeline of bifunctional antibodies that exploit the recent advances in immuno-oncology.
Invetx
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Invetx is a veterinary therapeutics company that focuses on biopharmaceuticals that bring human biotechnology to animal health.
Samsara Therapeutics
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Samsara Therapeutics is a biopharmaceutical company that aims to discover therapeutics to treat rare genetic and neurodegenerative disease.
Ally Therapeutics
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Ally Therapeutics solves the immune response barriers for gene therapy.
EIP Pharma
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EIP Pharma is a Developer of a central nervous system focused drugs intended to offer treatment for Alzheimer’s Disease.
LikeMinds
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LikeMinds is a biotech company that develops Neupro, a transdermal movement disorder drug for Parkinson’s and Restless Legs Syndrome.
Civitas Therapeutics
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Civitas Therapeutics is a biopharmaceutical company that focuses on developing pulmonary delivery therapies.
Axol Bioscience
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Axol Bioscience sells live human cell cultures and provides services such as genome editing to researchers.
Anodyne Nanotech
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Anodyne Nanotech is a preclinical-stage biotech company that develops differentiated, transdermal forms of high-value drugs.
Nirogy Therapeutics
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Nirogy Therapeutics is focusing on small-molecule drugs that target the solute carrier family of transporter proteins (SLCTs).
Exonics Therapeutics
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Exonics Therapeutics, a Boston, Mass.-based biotechnology company.
Tetraphase Pharmaceuticals
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Tetraphase Pharmaceuticals is a company leveraging a dynamic drug engine targeted at several significant disease categories.
LabMinds
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Solution Preparation via Automation – The Revo ® solution preparation system utilizes robotics, artificial intelligence and machine learning
Potenza Therapeutics
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Potenza Therapeutics is a preclinical-stage biotechnology company focused on building a portfolio of oncology programs.
Silk Therapeutics
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Silk Therapeutics is a biotech company that offers skincare products for human health and wellness.
MarvelBiome
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MarvelBiome focuses on isolating, identifying, and characterizing microbial populations for novel therapeutic applications.
DeepBiome Therapeutics
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DeepBiome Therapeutics is an operator of a biotechnology company intended to develop a new drug discovery platform.
Acusphere
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Acusphere is a speciality pharmaceutical company developing cardiovascular drugs for the detection of coronary artery disease.
Berkshire Sterile Manufacturing (BSM)
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Berkshire Sterile Manufacturing (BSM) is a Biotechnology company.
Rubix LS
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Rubix LS primary goal is to eradicate rare diseases through transformative research and development, breakthroughs in engineering.
Promedior
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Promedior is a biopharmaceutical company developing novel therapeutics for the treatment of inflammatory and fibrotic diseases.
Revere Pharmaceuticals
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Revere Pharmaceuticals is an oncology-focused biotechnology company leading the development of small molecule therapeutics.
BioFeyn
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BioFeyn is enhancing the efficiency and sustainability of marine ingredients for use in aquaculture.
Lowell Therapeutics
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Lowell Therapeutics is a pharmaceutical company that develops products for critically ill patients.
Artax Biopharma
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Artax Biopharma is a biopharmaceutical company that develops new therapies for autoimmune and inflammatory diseases.
SmartPharm Therapeutics
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SmartPharm Therapeutics is a second-generation gene-encoded therapeutics company.
Alloplex Biotherapeutics
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Alloplex Biotherapeutics is a privately held Boston based cellular therapeutics company.
Quad Technologies
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Quad Technologies is a biotechnology company that specializes in cell separation technologies.
Snapdragon Chemistry
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Snapdragon Chemistry focus on developing practical manufacturing solutions for challenging chemical transformations.
PAREXEL
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PAREXEL is a biopharmaceutical services company that focuses on the development and commercialization of new medical therapies worldwide.
Molecular Loop
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Molecular Loop is a biotechnology company that specializes in DNA sequencing.
Symbiosis Pharmaceutical Services
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A leading GMP contract manufacturer of novel injectable pharmaceuticals for use in clinical trials.
Protein Dynamic Solutions
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Biotherapeutics Analytical Instrumentation for AI, R&D and Manufacturing [ HT multi-attribute multi-variate (MAM) and label free analysis].
Piper Therapeutics
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Drug discovery and development for moderating macrophages, with initial focus on immuno-oncology
Virex Health
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Virex is a biotechnology firm that enables widespread testing in life, homes, workplaces, schools, and public spaces globally.
SanaRx Biotherapeutics
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SanaRx Biotherapeutics is designed to improve detection, visualization and treatment of 3 rare diseases.
Cellaria
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Cellaria is a scientific innovator that is revolutionizing cancer research, patient testing, and treatment development.
Annovation BioPharma
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Annovation BioPharma develops pharmaceutical products for anesthesia, sedation and sleep.
CorEvitas
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CorEvitas delivers real-world evidence through syndicated registry data and analytics services to help biopharmaceutical companies.
Akashi Therapeutics
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Akashi Therapeutics is a clinical stage biopharmaceutical company.
Genzyme
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Genzyme Corporation (Genzyme) is a biotechnology company. The Company’s product and service portfolio is focused on rare genetic disease
JB Therapeutics
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JB Therapeutics is a clinical-stage biopharmaceutical company developing innovative therapies for orphan inflammatory diseases.
Totus Medicines
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Totus Medicines is a provider of chemical biology technologies by creating life-changing covalent drugs.
Oxygen Therapy
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Oxygen Therapy is a biopharma company that develops anti-necrosis drugs that treat a variety of medical conditions resulting from Ischemia.
Kbiobox
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KBiobox offers applications built upon the technology of gene editing design, off-target analysis, and extended GUIDEseq analysis.
AesRx
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AesRx is a biopharmaceutical company dedicated to the development of two novel drugs, Aes-103 and Aes-210, which targets orphan diseases.
Tarpon Biosystems
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Tarpon Biosystems technology provides patented purification technologies for the biomanufacturing environment.
Olaris
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Olaris is a biotechnology company that specializes in producing personalized biomarkers of response.
Takeda Oncology
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Takeda Oncology is a leading biopharmaceutical company.
Spherics
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Spherics engages in developing and manufacturing oral pharmaceutical products.
