101 Best Massachusetts Medical Device Companies and Startups

October 27, 2021
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This article showcases our top picks for the best Massachusetts based Medical Device companies. These startups and companies are taking a variety of approaches to innovating the Medical Device industry, but are all exceptional companies well worth a follow.

We tried to pick companies across the size spectrum from cutting edge startups to established brands.

We selected these startups and companies for exceptional performance in one of these categories:

  • Innovation
    • Innovative ideas
    • Innovative route to market
    • Innovative product
  • Growth
    • Exceptional growth
    • Exceptional growth strategy
  • Management
  • Societal impact

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Top Massachusetts Medical Device Startups

Data sourced from Crunchbase and SemRush.

Boston Scientific

Boston Scientific

Crunchbase Website Twitter Facebook Linkedin

Boston Scientific is an innovator of medical solutions that improve the health of patients around the world.

Activ Surgical

Activ Surgical

Crunchbase Website Twitter Facebook Linkedin

Activ Surgical is a digital surgery company focused on improving surgical efficiency, accuracy, patient outcomes, and accessibility.

Activ Surgical

Spero Therapeutics

Crunchbase Website Twitter Facebook Linkedin

Spero Therapeutics is developing first in class therapeutics for treatment of Gram-negative infections.

Activ Surgical

Iora Health

Crunchbase Website Twitter Facebook Linkedin

Iora Health is a healthcare company that helps patients manage their health and navigate the healthcare system.

Activ Surgical

Rewalk Robotics

Crunchbase Website Twitter Facebook Linkedin

Rewalk Robotics provides a commercial walking assistance system for people with lower limb disabilities.

Activ Surgical

Agenus

Crunchbase Website Twitter Facebook Linkedin

Agenus develops and commercializes immunotherapies and vaccines for cancer and infectious diseases.

Activ Surgical

Current Health

Crunchbase Website Twitter Facebook Linkedin

We help healthcare reduce risk & cost by monitoring, managing and engaging patients at home.

Activ Surgical

Wave Life Sciences

Crunchbase Website Twitter Facebook Linkedin

WaVe Life Sciences specializes in the development of next-generation nucleic acids for therapeutic and diagnostic applications.

Activ Surgical

1upHealth

Crunchbase Website Twitter Facebook Linkedin

1upHealth is a health-tech company that builds products for the future of healthcare.

Activ Surgical

Ribon Therapeutics

Crunchbase Website Twitter Facebook Linkedin

Ribon Therapeutics is a biotechnology company focused on the development of therapeutics treatments targeting stress support pathways.

Activ Surgical

Ocular Therapeutix

Crunchbase Website Twitter Facebook Linkedin

Ocular Therapeutix develops and commercializes ophthalmic therapeutic products by using hydrogel technology.

Activ Surgical

Allurion Technologies

Crunchbase Website Twitter Facebook Linkedin

Allurion Technologies develops a medical device for weight loss that can be delivered and removed without surgery or endoscopy.

Activ Surgical

Qstream

Crunchbase Website Twitter Facebook Linkedin

Qstream is a microlearning platform that quantifiably improves job proficiency and changes behavior that results in teams who excel.

Activ Surgical

Binx Health

Crunchbase Website Twitter Facebook Linkedin

Binx Health creates new categories of healthcare solutions that deliver on-demand testing to people where they need it most.

Activ Surgical

Cullinan Oncology

Crunchbase Website Twitter Facebook Linkedin

Cullinan Oncology is a developer of an externally sourced cancer therapeutics intended to end a drug program quickly if the early research.

Activ Surgical

Haemonetics

Crunchbase Website Twitter Facebook Linkedin

Haemonetics is a provider of blood and plasma supplies and services.

Activ Surgical

Fractyl Health

Crunchbase Website Twitter Facebook Linkedin

Fractyl Health is a biotechnology company that provides curative therapies for metabolic diseases.

Activ Surgical

Decibel Therapeutics

Crunchbase Website Twitter Facebook Linkedin

Decibel Therapeutics is a hearing company focused on discovering and developing new medicines to protect, repair, and restore hearing.

Activ Surgical

NeuroMetrix

Crunchbase Website Twitter Facebook Linkedin

NeuroMetrix is a medical device company focused on the diagnosis and treatment of the neurological complications of diabetes.

Activ Surgical

Beacon Biosignals

Crunchbase Website Twitter Facebook Linkedin

Beacon’s goal is to improve human health by applying artificial intelligence to brain activity.

Activ Surgical

Intrinsic Therapeutics

Crunchbase Website Twitter Facebook Linkedin

Intrinsic Therapeutics is a medical device company that develops therapies to treat disc herniations in the spine for discectomy patients.

Activ Surgical

XRHealth

Crunchbase Website Twitter Facebook Linkedin

XRHealth is a telemedicine startup building a VR platform that enables remote treatment.

Activ Surgical

Beta Bionics

Crunchbase Website Twitter Facebook Linkedin

Beta Bionics is a biotechnology company that develops an integrated bionic pancreas system called the iLet.

Activ Surgical

Keystone Dental

Crunchbase Website Twitter Facebook Linkedin

Keystone Dental is an oral healthcare company delivering advanced, easy-to-use implants, biomaterials and planning software.

Activ Surgical

Inivata

Crunchbase Website Twitter Facebook Linkedin

Inivata is a clinical cancer genomics company harnessing the emerging potential of circulating DNA analysis.

Activ Surgical

Baystate Health

Crunchbase Website Twitter Facebook Linkedin

Baystate Health is an integrated health care delivery system serving a population of nearly one million people in western Massachusetts.

Activ Surgical

TransMedics

Crunchbase Website Twitter Facebook Linkedin

Transmedics is a medical device company involved in the design and production of transplant devices.

Activ Surgical

ConforMIS

Crunchbase Website Twitter Facebook Linkedin

ConforMIS develops personalized, patient-specific implants and instrumentation for knee-related therapeutics.

Activ Surgical

Glympse Bio

Crunchbase Website Twitter Facebook Linkedin

Glympse Bio is a biotechnology company that transforms disease detection and predict treatment response.

Activ Surgical

OncXerna Therapeutics

Crunchbase Website Twitter Facebook Linkedin

OncXerna Therapeutics offers precision medicine using an innovative RNA-based biomarker platform.

Activ Surgical

Sesen Bio, Inc.

Crunchbase Website Twitter Facebook Linkedin

Sesen Bio, Inc. is focused on developing innovative protein-based therapeutics to improve human health and treat diseases.

Activ Surgical

Checkmate Pharmaceuticals

Crunchbase Website Twitter Facebook Linkedin

Checkmate Pharma is a clinical stage biopharmaceutical company developing a new approach for cancer immunotherapy.

Activ Surgical

Elucid

Crunchbase Website Twitter Facebook Linkedin

Elucid improves accuracy, experience, and cost-effectiveness of cardiovascular diagnostic imaging.

Activ Surgical

Podimetrics

Crunchbase Website Twitter Facebook Linkedin

Podimetrics is a care management company with the leading solution to help prevent diabetic foot ulcers.

Activ Surgical

Fresenius Medical Care North America

Crunchbase Website Twitter Facebook Linkedin

Fresenius Medical Care North America provides healthcare services to people with renal and other chronic conditions.

Activ Surgical

Ivenix

Crunchbase Website Twitter Facebook Linkedin

Ivenix is a medical technology company that develops a next-generation infusion management system.

Activ Surgical

Apnimed

Crunchbase Website Twitter Facebook Linkedin

Apnimed is a clinical-stage company dedicated to the discovery of novel pharmacologic therapies for sleep apnea and related disorders.

Activ Surgical

Convergent Dental

Crunchbase Website Twitter Facebook Linkedin

Convergent Dental develops a computer-guided, laser-based drilling and cutting system for dentists.

Activ Surgical

CardioFocus

Crunchbase Website Twitter Facebook Linkedin

CardioFocus is a biotechnology company that focuses on the advancement of ablation treatments for cardiac disorders.

Activ Surgical

Invo Bioscience

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INVO Bioscience is a medical device company founded by Claude Ranoux, MD, MS, a noted expert in the field of reproductive health,

Activ Surgical

Goldfinch Biopharma

Crunchbase Website Twitter Facebook Linkedin

Goldfinch is a clinical-stage biotech company focused on discovering and developing precision therapies for patients with kidney disease.

Activ Surgical

Gelesis

Crunchbase Website Twitter Facebook Linkedin

Gelesis is a biotechnology company developing first-in-class therapeutics to safely treat obese, overweight, and diabetic patients.

Activ Surgical

AcuityMD

Crunchbase Website Twitter Facebook Linkedin

AcuityMD provides a platform for commercializing and improving medical devices with data.

Activ Surgical

InfoBionic

Crunchbase Website Twitter Facebook Linkedin

InfoBionic transforms the efficiency and the economics of ambulatory remote patient monitoring processes and cardiac diagnostic services.

Activ Surgical

Corindus

Crunchbase Website Twitter Facebook Linkedin

Corindus develops and commercializes remote robotic systems for interventional procedures.

Activ Surgical

Windgap Medical

Crunchbase Website Twitter Facebook Linkedin

WindGap Medical is a biotech company that manufactures medical devices used to treat patients with severe allergies.

Activ Surgical

Vocalis Health

Crunchbase Website Twitter Facebook Linkedin

Vocalis Health is to develop AI platform to enable healthcare.

Activ Surgical

Day Zero Diagnostics

Crunchbase Website Twitter Facebook Linkedin

The future of infectious disease diagnostics starts at Day Zero.

Activ Surgical

Clora

Crunchbase Website Twitter Facebook Linkedin

Clora is an intelligent platform that matches life science companies with flexible, on-demand expertise.

Activ Surgical

Alcresta

Crunchbase Website Twitter Facebook Linkedin

Alcresta develops enzyme-based nutritional products for infants and adults with acute and chronic diseases.

Activ Surgical

Access Vascular

Crunchbase Website Twitter Facebook Linkedin

Access Vascular is a medical device company that develops novel bulk hydrophilic-based devices to improve venous access.

Activ Surgical

Portal Instruments

Crunchbase Website Twitter Facebook Linkedin

Portal Instruments is an early stage, Series A funded, medical device company.

Activ Surgical

QMENTA

Crunchbase Website Twitter Facebook Linkedin

QMENTA is a medical image analysis platform that helps specialists provide better diagnosis and treatment for patients with brain diseases.

Activ Surgical

Etiometry

Crunchbase Website Twitter Facebook Linkedin

Etiometry is a provider of next-generation patient monitoring software and advanced analytics for hospital ICUs.

Activ Surgical

Boston MicroFluidics

Crunchbase Website Twitter Facebook Linkedin

Boston MicroFluidics specializes in developing medical devices, point-of-care devices, capillary tubes, and disposable design.

Activ Surgical

Spectrawave

Crunchbase Website Twitter Facebook Linkedin

Spectrawave is a medical device company that develops optical diagnostic and therapeutic devices.

Activ Surgical

IQ Endoscopes

Crunchbase Website Twitter Facebook Linkedin

IQ Endoscopes is a range of single-use flexible endoscopes that provides images of the full length.

Activ Surgical

Biodirection

Crunchbase Website Twitter Facebook Linkedin

BioDirection is a medical device company commercializing hand-held point-of-care products for screening and monitoring mild brain injury.

Activ Surgical

Respiratory Motion

Crunchbase Website Twitter Facebook Linkedin

Respiratory Motion ExSpiron is FDA and CE Mark cleared and non-invasively measures minute ventilation, the fundamental unit of breathing.

Activ Surgical

UpToDate

Crunchbase Website Twitter Facebook Linkedin

UpToDate’s mission is to help clinicians provide the best possible care for their patients.

Activ Surgical

Pirouette Medical

Crunchbase Website Twitter Facebook Linkedin

Pirouette Medical develops a portable, intuitive, and easy-to-use auto-injector.

Activ Surgical

Cadent Therapeutics

Crunchbase Website Twitter Facebook Linkedin

Cadent Therapeutics develops novel medicines that tune and modulate brain rhythms for patients with serious neurological disease.

Activ Surgical

Cue Biopharma

Crunchbase Website Twitter Facebook Linkedin

Cue Biopharma has developed a highly productive platform for the treatment of cancer and autoimmune disease.

Activ Surgical

Hyalex Orthopaedics

Crunchbase Website Twitter Facebook Linkedin

A Boston-area medical device company advancing new products that feature HYALEX™ technology, a polymer that is designed to mimic cartilage

Activ Surgical

Corvia Medical

Crunchbase Website Twitter Facebook Linkedin

Corvia Medical develops transcatheter device designed to reduce the symptoms or slow the progression of heart failure.

Activ Surgical

RevBio

Crunchbase Website Twitter Facebook Linkedin

RevBio is developing the first bone adhesive to repair bone fractures and stabilize metal implants.

Activ Surgical

MYOMO

Crunchbase Website Twitter Facebook Linkedin

Myomo develops devices with myoelectric prosthetic technology to restore the mobility of individuals with muscle weakness.

Activ Surgical

Miach Orthopaedics

Crunchbase Website Twitter Facebook Linkedin

Miach Orthopaedics is a medical device company that designs technologies intended to facilitate new tissue growth.

Activ Surgical

Tepha

Crunchbase Website Twitter Facebook Linkedin

Tepha is a medical device firm developing and commercializing a new class of absorbable biomaterials to be used in surgical procedures.

Activ Surgical

GRO Biosciences

Crunchbase Website Twitter Facebook Linkedin

GRO Biosciences transforms protein therapeutics with new amino acid building blocks to treat incurable diseases.

Activ Surgical

OmniGuide

Crunchbase Website Twitter Facebook Linkedin

OmniGuide is a medical device company developing and commercializing minimally-invasive surgical tools.

Activ Surgical

Daktari Diagnostics

Crunchbase Website Twitter Facebook Linkedin

Daktari Diagnostics manufactures diagnostic medical products for clinicians and patients.

Activ Surgical

Lantos Technologies

Crunchbase Website Twitter Facebook Linkedin

Lantos Technologies makes the only FDA-cleared 3D ear scanning system that enables custom, in-ear products

Activ Surgical

Biostage

Crunchbase Website Twitter Facebook Linkedin

Biostage is a biotechnology company developing next-generation esophageal implants for patients battling life-threatening conditions.

Activ Surgical

Mobius Imaging

Crunchbase Website Twitter Facebook Linkedin

Mobius Imaging is a medical devices company providing mobile computed tomography and medical imaging solutions.

Activ Surgical

Arsenal Medical

Crunchbase Website Twitter Facebook Linkedin

Arsenal Medical develops novel products that improve local therapy for injuries and diseases.

Activ Surgical

Cognoptix

Crunchbase Website Twitter Facebook Linkedin

Cognoptix develops non-invasive eye tests for the early diagnosis of alzheimer disease.

Activ Surgical

Instylla

Crunchbase Website Twitter Facebook Linkedin

Instylla’s focus is to leverage hydrogel technology .

Activ Surgical

Ossio

Crunchbase Website Twitter Facebook Linkedin

Ossio is an orthopedic medical device company.

Activ Surgical

InVivo Therapeutics

Crunchbase Website Twitter Facebook Linkedin

InVivo Therapeutics is a medical device company focused on developing restoration treatments for patients with spinal cord-injuries.

Activ Surgical

Reprieve Cardiovascular

Crunchbase Website Twitter Facebook Linkedin

Reprieve Cardiovascular is focused on improving outcomes for patients suffering from acute decompensated heart failure.

Activ Surgical

GI Dynamics

Crunchbase Website Twitter Facebook Linkedin

GI Dynamics is a medical device company developing therapies for the treatment of type 2 diabetes and related metabolic diseases.

Activ Surgical

TearClear

Crunchbase Website Twitter Facebook Linkedin

TearClear is a pharmaceutical company that specializes in providing a disruptive eye health technology.

Activ Surgical

BioSensics

Crunchbase Website Twitter Facebook Linkedin

BioSensics is a globally recognized provider of wearable sensor technologies for clinical research and medical applications

Activ Surgical

CereVasc

Crunchbase Website Twitter Facebook Linkedin

CereVasc is a medical device company focused on improving the treatment of patients with hydrocephalus.

Activ Surgical

G.I. Windows

Crunchbase Website Twitter Facebook Linkedin

G.I. Windows is a clinical-stage company developing the first fundamental breakthrough in surgical anastomotic technology.

Activ Surgical

OMNIlife science

Crunchbase Website Twitter Facebook Linkedin

OMNIlife science, Inc. was founded in 1999 as an organization committed to the design, manufacture and distribution of high quality

Activ Surgical

NinePoint Medical

Crunchbase Website Twitter Facebook Linkedin

NinePoint Medical is a transformational medical device company developing innovative, real-time, in vivo pathology devices.

Activ Surgical

InfraReDx

Crunchbase Website Twitter Facebook Linkedin

InfraReDx designs and develops intelligent catheter-based coronary imaging devices.

Activ Surgical

Common Sensing

Crunchbase Website Twitter Facebook Linkedin

Common Sensing develops and manufactures data-driven hardware and software solutions for people using injectable medicine.

Activ Surgical

EyeNetra

Crunchbase Website Twitter Facebook Linkedin

EyeNetra is a developer of an eye diagnostics platform used to measure the correction of users’ vision through smartphone-based technology.

Activ Surgical

SpaceOAR

Crunchbase Website Twitter Facebook Linkedin

SpaceOAR is a medical device company that develops space-filling hydrogels for radiation oncology and cancer surgery indications.

Activ Surgical

Rebion

Crunchbase Website Twitter Facebook Linkedin

Rebion specializes in data analytics firm developing pediatric vision scanners to detect serious eye conditions.

Activ Surgical

American Renal Associates Holdings

Crunchbase Website Twitter Facebook Linkedin

American Renal Associates Holdings operates kidney dialysis services and offers outpatient and inpatient dialysis treatments.

Activ Surgical

Exonics Therapeutics

Crunchbase Website Twitter Facebook Linkedin

Exonics Therapeutics, a Boston, Mass.-based biotechnology company.

Activ Surgical

SynapDx

Crunchbase Website Twitter Facebook Linkedin

SynapDX is an early-stage laboratory services company developing blood-based diagnostic tests for the early detection of autism.

Activ Surgical

Bluejay Diagnostics

Crunchbase Website Twitter Facebook Linkedin

Bluejay Diagnostics is a manufacturing company

Activ Surgical

Acetylon Pharmaceuticals

Crunchbase Website Twitter Facebook Linkedin

Acetylon Pharmaceuticals manufactures small molecule drugs to realize the therapeutic potential of histone deacetylase.

Activ Surgical

Suono Bio

Crunchbase Website Twitter Facebook Linkedin

Suono Bio is developing platform technology designed to enable ultra-rapid delivery of therapeutics.

Activ Surgical

Andiamo

Crunchbase Website Twitter Facebook Linkedin

Connected medical devices for the treatment of cerebral palsy

Activ Surgical

Solace Therapeutics

Crunchbase Website Twitter Facebook Linkedin

Solace Therapeutics develops and commercializes non-surgical office-based treatments for common bladder disorders.

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