Mark Smith
This article showcases our top picks for the best Minnesota based Biotechnology companies. These startups and companies are taking a variety of approaches to innovating the Biotechnology industry, but are all exceptional companies well worth a follow.
We tried to pick companies across the size spectrum from cutting edge startups to established brands.
We selected these startups and companies for exceptional performance in one of these categories:
- Innovation
- Innovative ideas
- Innovative route to market
- Innovative product
- Growth
- Exceptional growth
- Exceptional growth strategy
- Management
- Societal impact
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Top Minnesota Biotechnology Startups
Data sourced from Crunchbase and SemRush.
Medtronic
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Medtronic develops and manufactures medical device technologies and therapies to treat chronic diseases worldwide.
Mayo Clinic
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MayoClinic is a nonprofit medical practice and medical research group focused on integrated health care, education, and research.
Miromatrix Medical
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Miromatrix Medical is engaged in the development of fully biological human organs and organ-derived biological products.
CVRx
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CVRx is a medical device company developing implantable technology for the treatment of high blood pressure.
Inspire Medical Systems
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Inspire Medical Systems develops implantable therapeutic devices for the treatment of obstructive sleep apnea.
Vireo Health
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Vireo Health is a physician-led company dedicated to providing patients with best-in-class cannabis-based products and high quality care
Relievant Medsystems
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Relievant provides patients with low risk therapy that affords the ability to alleviate their back pain.
Nuvaira
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Nuvaira is a new alternative COPD treatment option that specializes in developing devices for treating lung diseases.
Panbela Therapeutics
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Panbela Therapeutics develops small molecule pharmaceuticals for the oncology and acute care markets.
Calyxt
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Calyxt is an Agbiotech company focused on developing crops with healthier characteristics
Recombinetics
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Recombinetics targets biomedical and regenerative medicine, opening vast new opportunities to improve and extend human life.
ANI Pharmaceuticals
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ANI Pharmaceuticals manufactures oral solid dose products, as well as liquids and topicals.
EnteroMedics
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EnteroMedics® Inc. (NASDAQ: ETRM) is the developer of in-class weight loss treatments for obesity and obesity related risk factors.
Conventus Orthopaedics
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Conventus Orthopaedics is a provider of a range of orthopedic and sports medicine services.
StemoniX
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StemoniX is a biotechnology company that focuses on stem cell technologies to meet the demands of drug discovery and personalized medicine.
NeoChord
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NeoChord is a medical device company that develops devices that allow mitral valve repair to be performed on a beating heart.
BioAmber
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BioAmber is a sustainable chemicals firm combining biotechnology and chemical catalysis to convert renewable feedstock into chemicals.
Ativa Medical
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Ativa Medical is working to make diagnostic test results available in moments, rather than hours and days.
Rebiotix
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Rebiotix is a development-stage biotechnology company focusing on the treatment of GI diseases by developing human microbiome.
Biothera
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Biothera is a biotechnology company developing natural gluco polysaccharides that engage and direct natural innate immune systems.
Humanetics Corporation
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clinical stage pharmaceutical company.
NxThera
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NxThera develops medical technologies to treat a variety of endourology conditions, including BPH.
Cardiovascular Systems
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Cardiovascular Systems develops and markets medical devices for the treatment of cardiovascular disease.
Entellus Medical
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Entellus Medical develops technology-based treatment solutions for ENT physicians, their patients and payers.
CHF Solutions
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CHF Solutions is a medical device company that focuses on innovative cardiac assist therapy to treat patients.
Silk Technologies
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SILKTECH focuses on innovating and developing silk-derived protein (SDP) products for ophthalmic applications
Celcuity
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Celcuity transform care for patients with cancer or autoimmune disease.
OneOme
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OneOme is a collaborative concern between the business builder .
Neuroone Medical Technologies
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NeuroOne is a medical technology company focused on improving surgical care for patients suffering from neurological disorders.
Osprey Medical
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Osprey Medical develops and commercializes its propriety CINCOR™ System designed for the prevention of contrast induced mephropathy.
Rotation Medical
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Rotation Medical develops treatments for rotator cuff disease by reversing disease progression and restoring long-term shoulder function.
Imbio
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Imbio develops medical imaging software solutions that save lives and reduce costs.
Metavention
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Metavention develops medical devices to help with interventional therapies for Type 2 diabetes.
Marker Therapeutics
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Marker Therapeutics is a clinical-stage developer of a transformative, non-genetically engineered, multi-antigen T cell therapy platform.
Torax Medical
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Torax Medical develops an implantable device for the treatment of gastroesophageal reflux disease.
Vyriad
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Vyriad is a clinical stage biopharmaceutical company.
DiaMedica
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DiaMedica is a biopharmaceutical company focused on developing innovative treatments for stroke.
Cogentix Medical
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Cogentix Medical products have increased treatment efficiency and lowered patient risk.
Imricor Medical Systems
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Imricor Medical Systems develops magnetic resonance imaging compatible electrophysiology tools for the treatment of cardiac arrhythmias.
Venture Med Group
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VMG designs, develops which enable interventionalists to cost effectively treat peripheral artery diseases.
Cryosa
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CryOSA is a medical device company developing novel treatments for obstructive sleep apnea.
Reprise Biomedical
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Reprise Biomedical focuses on the development and commercialization of biological medical devices.
FOXO Technologies
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FOXO Technologies is transforming the global longevity insurance industry with a next-generation underwriting protocol.
Luminary Therapeutics
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Luminary Therapeutic is a cancer research center that develops pre-clinical stage cell therapy for cancer and autoimmune diseases.
CardiaLen
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CardiaLen develops and commercializes pain-free cardioversion therapies for atrial fibrillation.
MicroOptx
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MicroOptx is an early-stage medical device company that leverages academic bioengineering.
Preceptis Medical
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Preceptis Medical develops surgical tools that allow ear tube procedures to be performed with less pain.
Tendyne Holdings
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Tendyne is a medical device company developing a transcatheter aortic valve implantation system.
Vergent Bioscience
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Vergent Bioscience is a biotech company leading the development of tumor-targeted molecular imaging molecules for cancer surgery.
CoreBiome
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Provides fast, accurate genomic profiles of microbial communities to customers in pharmaceutical, agriculture, and academic research.
JanOne
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JanOne is a pharmaceutical company focused on finding treatments for conditions that cause severe pain and bringing to market drugs.
Vixar
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Vixar develops optical components and subassemblies for sensor applications in the biomedical, industrial, and automotive industries.
Geneticure
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Geneticure is a personalized medicine company with patented tests that control chronic diseases faster than trial/error, with less cost
AUM Cardiovascular
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AUM Cardiovascular is a medical device manufacturing company that specializes in the fields of biotechnology, medical, and healthcare.
Canomiks
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Canomiks’ genomics, bioinformatics, and AI-based Product Superiority Platform helps companies create safe and efficacious products.
SpineThera
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SpineThera develops novel, sustained-release, injectable drugs to treat pain.
Veravas
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Veravas is a company that develops high value solutions for the accurate diagnosis of the world’s most devastating diseases.
Aurora Pharmaceutical
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Aurora Pharmaceutical is a veterinary pharmaceutical company that develops and manufactures veterinary pharmaceutical products.
Insitu Biologics
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InSitu Biologics is a developer of a drug delivery platform designed to focus on development of new and proprietary treatments.
Segetis
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Segetis is transforming the chemical industry by offering unique material properties, cost effective economics.
Augustine Temperature Management
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Augustine Temperature Management develops conductive fabric patient warming systems for surgical patients in the United States.
Nirva Medical
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Nirva Medical is a medical device start up focusing on organ-specific therapy-delivery technology for various clinical applications.
OX2 Therapeutics
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OX2 Therapeutics is a healthcare therapeutics company that focuses on treating brain tumors.
Stratix Labs
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Stratix Labs develops and markets innovative microbiology products for research, development, and quality control applications.
LEAH Labs
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LEAH Labs provides Car T cells for curing B-cell lymphoma cancer in dogs .
RoverMed BioSciences
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RoverMed has developed precision targeted nanocapsule technology aimed at delivering life saving drugs to the most challenging disease sites
Cardia
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Cardia is an innovative company engaged in developing, manufacturing and marketing transcatheter septal occluders.
Phenomix Sciences
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Phenomix Sciences is a biotechnology company that specializes in biotech, life science, metabolomics, and genomics.
CranioVation
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CranioVation is an innovative solution to treat aggressive brain tumors using light delivered via a minimally invasive device.
B-MoGen Biotechnologies
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B-MoGen Biotechnologies is a genome engineering startup out of Minneapolis, MN.
EmboMedics
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EmboMedics develops and commercializes resorbable and drug-loaded embolization devices for the treatment of multiple indications.
Pelvital
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Pelvital is a privately held company that restores Pelvic Health and improve the lives of people.
GRIP Molecular Technologies
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GRIP Molecular is a molecular detection device used at point-of-care to enable the rapid identification of chemical and biological threats.
Protégé Biomedical
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Protégé Biomedical is a company with a unique new line of hemostatic products developed to stop bleeding in animals and humans*.
CNS Therapeutics (Old)
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CNS Therapeutics develops pharmaceuticals for the treatment of neurological disorders and chronic pain.
Delve Health
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Market place for clinical literature reviews and publications.
Uromedica
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Uromedica is a medical device company developing an adjustable balloon device for stress urinary incontinence (SUI).
Biomedix vascular solution
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Biomedix, a health care technology company, builds and supports community-based collaborative health care networks.
SubioMed
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SubioMed specializes in the invention and development of suspension biomechanics technology addressing gait and balance.
Imanis Life Sciences
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Imanis is a biotechnology company that specializes in oncolytic virotherapy and reporter gene imaging.
Zurich Medical
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Zurich Medical develops proprietary medical devices.
BRTI Life Sciences
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BRTI Life Sciences concentrates on cell research and therapeutics.
Prism Clinical Research
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Prism Clinical Research is a research company offering medical research services.
Mill Creek Life Sciences
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Mill Creek Life Sciences provides tools and technologies to support the development and application of cellular and biologic therapeutics.
Tychon Bioscience
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Tychon Bioscience is a biotechnology company commercializing adaptive immunotherapy technology.
GT Urological
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GT Urological, LLC develops, manufactures, distributes, and markets medical devices for the urinary incontinence market.
Cambridge Technologies
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Cambridge Technologies is an independent owner-operated custom vaccine company working with veterinarians and livestock producers.
Wound Care Technologies
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Wound Care Technologies, a medical technology company, develops and markets external tissue expansion devices for the wound care market.
Shape Medical Systems
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Shape Medical Systems develops cardiopulmonary exercise testing technology to improve the early detection and treatment of heart failure.
Medafor
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Medafor develops novel hemostatic technology and absorbable hemostats called MPH(R), which accelerates the normal blood clotting process.
Hennepin Life Sciences
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Hennepin Life Sciences is a University of Minnesota spin-out developing treatments for women’s health conditions.
Martell Diagnostic Laboratories
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Martell Diagnostic Laboratories is a Biotechnology company.
Dgimed Ortho
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DGIMed Ortho is an early-stage orthopedic trauma company that develops an intramedullary nailing system and distal targeting device.
CloSys
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CloSys develops hemostatic devices used for rapid vascular closure for anti-coagulated patients.
InterValve
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InterValve develops medical devices and technology for the catheter-based treatment of calcified aortic valve stenosis.
Circle Biologics
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Circle Biologics develops and markets biologic treatments and intra-operative biologic material management systems.
Vertical Health Solutions
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Vertical Health Solutions develops MRI quality assurance software technologies to hospitals and imaging centers in the U.S.
Prospex Medical
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Prospex Medical is a medical device incubator focused on innovating and incubating novel medical technologies.
Bio-Techne
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Bio-Techne is a supplier of high quality and innovative tools for Life Science Research, Therapeutic Manufacturing and Clinical Diagnostics.
Hypertension Diagnostics
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Hypertension Diagnostics designs and manufactures non-invasive medical devices that detect subtle changes in the elasticity of arteries.
