101 Top San Francisco Software Companies and Startups of 2021

June 18, 2021

This article showcases our top picks for the best San Francisco based Software companies. These startups and companies are taking a variety of approaches to innovating the Software industry, but are all exceptional companies well worth a follow.

We tried to pick companies across the size spectrum from cutting edge startups to established brands.

We selected these startups and companies for exceptional performance in one of these categories:

  • Innovation
    • Innovative ideas
    • Innovative route to market
    • Innovative product
  • Growth
    • Exceptional growth
    • Exceptional growth strategy
  • Management
  • Societal impact

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Top San Francisco Software Startups

Data sourced from Crunchbase and SemRush.

Plaid

Plaid

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Plaid provides companies with the tools and access needed for the development of a digitally-enabled financial system.

Cruise

Cruise

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Cruise builds self-driving vehicles that safely connect people to places, things, and experiences they care about.

Cruise

DocuSign

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DocuSign helps small- and medium-sized businesses collect information, automate data workflows, and sign on various devices.

Cruise

WalkMe

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WalkMe’s digital adoption platform enables organizations to measure, drive, and act to maximize the impact of their digital transformation.

Cruise

GitLab

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GitLab is a web-based open source Git repository manager with wiki and issue tracking features and built-in CI/CD.

Cruise

Fastly

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Fastly helps digital businesses keep pace with their customer expectations by delivering secure and online experiences.

Cruise

Fireflies.ai

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Fireflies.ai offers an AI Meeting assistant that records, transcribes, and makes searchable meeting notes.

Cruise

Iterable

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Iterable provides a marketing automation platform designed to optimize and measure every customer interaction.

Cruise

Pinterest

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Pinterest is a visual bookmarking tool for saving and discovering creative ideas.

Cruise

Shippo

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Shippo is a shipping platform that helps e-commerce companies manage their shipping operations more seamlessly.

Cruise

Skillz

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Skillz is a marketplace platform for competition-based mobile games.

Cruise

Razer

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Razer develops high-end precision gaming products by combining technology, ergonomics, and expert validation.

Cruise

Docker

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Docker provides an open platform for building, shipping, and running distributed applications.

Cruise

Carta

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Carta is building a global ownership management platform to help companies, investors, and employees manage their equity.

Cruise

GitHub

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GitHub provides code hosting services that allow developers/people to build software for open source and private projects in organizations.

Cruise

Bitwise

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Bitwise is a crypto index fund manager for individuals, investment managers, and institutions navigating cryptocurrency.

Cruise

Pipefy

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Pipefy specializes in the fields of process management, workflow, process automation, and task management.

Cruise

Okta

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Okta is a management platform that secures critical resources from cloud to ground for workforce and customers.

Cruise

Cloudflare

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Cloudflare is a web performance and security company that provides online services to protect and accelerate websites online.

Cruise

Dropbox

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Dropbox is a smart workspace company that provides secure file sharing, collaboration, and storage solutions.

Cruise

Datavant

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Datavant is a provider of a healthcare data solutions to help institutions share, protect, and match health data.

Cruise

HashiCorp

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HashiCorp is a remote-first company that solves development, security, and operations challenges in infrastructure.

Cruise

SpotOn

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SpotOn develops innovative software and payment solutions that help businesses increase revenue.

Cruise

Aurora Solar

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Aurora Solar is a SaaS company that uses aerial imagery to assess solar installation projects.

Cruise

Niantic

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Niantic builds augmented reality platform for current and future generations of AR hardware.

Cruise

Snapdocs

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Snapdocs is a mortgage technology company that helps real estate participants closing work together through integration and automation.

Cruise

Coda

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Coda is a new document that brings words, data, and teams together.

Cruise

Embroker

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Embroker helps growing businesses save time and find the best value on the right coverage.

Cruise

Contentstack

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Contentstack develops a cloud based content management system intended to power omnichannel content.

Cruise

Dialpad

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Dialpad is an AI-powered cloud communications platform that turns conversations into opportunities and helps teams make smart calls.

Cruise

Aclima

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Putting air pollution and greenhouse gases on the map, block by block, to reduce emissions, improve public health and advance equity.

Cruise

Lattice

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Lattice is a people management platform that empowers people leaders to build engaged, high-performing teams.

Cruise

Vanta

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Vanta is an automated security monitoring platform that helps companies get SOC 2, HIPAA, or ISO 27001 certified quickly.

Cruise

Twilio

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Twilio is a cloud communication company that enables users to use standard web languages to build voice, VoIP, and SMS apps via a web API.

Cruise

Gigster

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Gigster is the first team intelligence engine, enabling software development teams to achieve 30% higher efficiency.

Cruise

Chargebee

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Chargebee provides subscription and recurring billing systems for SaaS and e-commerce businesses.

Cruise

Samsara

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Samsara is the pioneer of the Connected Operations Cloud

Cruise

Sitecore

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Sitecore is a customer experience management company that provides multichannel marketing automation software and web content management.

Cruise

PagerDuty

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PagerDuty is an operations performance platform delivering visibility and actionable intelligence across the entire incident lifecycle.

Cruise

Algolia

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Algolia is the Search-as-a-Service platform that enables companies to deliver fast and relevant digital experiences that drive real results.

Cruise

People.ai

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People is an AI platform for enterprise sales, marketing, and customer success that uncovers every revenue opportunity from every customer.

Cruise

App Annie

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App Annie is a mobile data and analytics platformthat delivers data and insights to succeed in the app economy.

Cruise

Chorus.ai

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Chorus.ai is an AI conversation intelligence cloud platform for sales team that can transform conversations into data and insights.

Cruise

MURAL

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MURAL is a digital workspace for visual collaboration

Cruise

Grand Rounds Health

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Grand Rounds Health is a tech-driven healthcare company that offers an employer-based technology alternative for healthcare services.

Cruise

CircleCI

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CircleCI is a continuous integration and delivery platform that automates development workflows and IT operations.

Cruise

Discord

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Discord is an online voice, video and text service designed for hanging out with friends and creating communities around shared interests.

Cruise

Verily

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Verily develops tools and devices to collect and analyze health data to research and manage diseases.

Cruise

Heap

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Heap is a platform that provides analytics infrastructure to reduce the annoying parts of user analytics.

Cruise

New Relic

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New Relic is a digital intelligence company that delivers full-stack visibility and analytics to enterprises.

Cruise

Copper

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Copper offers customer relationship management solutions for companies that use Google applications.

RudderStack

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RudderStack is the CDP for developers.

Cruise

Medallia

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Medallia offers a SaaS platform that captures experience data from signal fields emitted by customers and employees.

Cruise

[redacted]

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Redacted is a cybersecurity provider that disrupts customer’s adversaries and protect their businesses.

Cruise

Census

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Census is a data automation platform that synchronizes customer’s data warehouses with business systems and tools.

Cruise

Ironclad

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Ironclad is one of the nation’s top makers of enterprise software for managing contracts

Cruise

PostHog

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PostHog provides a platform for open-source product analytics to helps software teams understand user behavior.

Cruise

Grammarly

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Grammarly’s digital writing assistant helps people write more clearly and effectively.

Cruise

MindTickle

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MindTickle is a software company that offers sales readiness and enablement tools for businesses.

Cruise

Planet

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Planet is an aerospace and data analytics company that builds small satellites and delivers information about the changing planet.

Cruise

ForgeRock

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ForgeRock is a multinational software company that develops commercial open source identity and access management products.

Cruise

Bright Machines

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Bright Machines brings together flexible factory robots with intelligent software, production data and machine learning.

Cruise

Forethought

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Forethought builds artificially intelligent agents to supercharge enterprise workflows, starting with Agatha, the AI for Customer Support.

Cruise

Doximity

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Doximity is the leading digital platform for medical professionals

Cruise

Intercom

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Conversational Relationship Platform helping businesses build customer relationships through personalized, messenger-based experiences.

Cruise

Expensify

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Expensify is a financial services startup that provides an integrated expense management and corporate card product for customers worldwide.

Cruise

Benchling

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Benchling is a cloud-based software platform for biology researchers and research and development organizations.

Cruise

HomeLight

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HomeLight is building the future of real estate — today.

Cruise

Aura Financial

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Aura is a financial service company that provides affordable, credit-building loans to working families.

Cruise

Qualio

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Qualio is a quality management system helping life sciences companies bring quality products to the market.

Cruise

Notion

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Notion is the all-in-one workspace for your notes, tasks, wikis, and databases

Cruise

Anaplan

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Anaplan provides a connected planning platform that helps businesses make better-informed plans and decisions faster.

Cruise

Crate.io

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Crate.io develops CrateDB, purpose-built to scale applications in a machine data world.

Cruise

Curebase

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Curebase is a provider of decentralized clinical research software solutions and services to patients and medical providers.

Cruise

Fundbox

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Fundbox is an AI-powered financial platform for small businesses.

Cruise

Honeycomb

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The fastest way to visualize, understand and debug software. Find the critical issues that logs and metrics can’t see.

Cruise

MuleSoft

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MuleSoft provides an integration and API platform that makes it easy to connect data from any system to create connected experiences.

Cruise

Zendesk

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Zendesk is a customer service platform that develops a software to empower organization and customer relationships.

Cruise

Komodo Health

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Komodo Health develops computer software that brings transparency and market intelligence to healthcare and life sciences.

Cruise

Vim

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Vim is a technology company building digital infrastructure for healthcare.

Cruise

Sentry

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Sentry is a developer of an application monitoring platform that helps developers monitor apps in real time to catch bugs early.

Cruise

Hive

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Hive provides cloud-based enterprise AI solutions designed for intelligent automation.

Cruise

MemSQL

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SingleStore is a provider of a database for operational analytics and cloud-native applications.

Cruise

MaintainX

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MaintainX is a mobile-first workflow management platform that allows factory frontline teams to know what they need to do and how to do it.

Cruise

Observe.AI

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Observe.AI is a software company that leverages AI, Natural Language Processing, and analytics to develop contact center software.

Cruise

Prismic

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Headless CMS with an API, CDN and a Writing Room

Cruise

Checkr

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Checkr seeks to automate the process of professional background checks.

Cruise

SightCall

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SightCall is a live video SaaS enabling visual support for enterprises enriched by Augmented Reality and Artificial Intelligence insights.

Cruise

Domino Data Lab

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Unleash the power of data science to address the world’s most important challenges.

Cruise

Specto

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Specto is a mobile application performance monitoring platform that collects vital metrics and profiles with just a few lines of code.

Cruise

Affinity

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Affinity is a relationship intelligence platform built to expand and evolve the traditional CRM.

Cruise

Pilot

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Pilot is a platform that offers bookkeeping, tax, and CFO services for growing businesses.

Cruise

OODA Health

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OODA Health is a healthcare technology company that offers a software billing platform for providers, payers, patients, and insurers.

Cruise

Vercel

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Vercel is a platform that enables users to develop, preview, and ship Jamstack sites.

Cruise

Sentieo

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Sentieo is a research platform that provides insights within the finance and corporate world.

Cruise

Rewatch

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Rewatch offers a private and secure video channel for teams.

Cruise

Pantheon

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Pantheon is the WebOps platform where marketers, designers and developers drive results with WordPress and Drupal websites.

Cruise

Amplitude

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Amplitude is a product intelligence platform that provides digital product tools that help teams run and grow their businesses.

Cruise

Standard Cognition

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Standard Cognition provides an autonomous checkout tool that can be installed into retailers’ existing stores.

Cruise

Journal

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Journal is a place to visually organize content from every app and website.

Cruise

UpGuard

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UpGuard is a cyber resilience platform, designed to proactively assess and manage the business risks posed by technology.

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