101 Top Minnesota Health Care Companies and Startups of 2021

July 5, 2021
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This article showcases our top picks for the best Minnesota based Health Care companies. These startups and companies are taking a variety of approaches to innovating the Health Care industry, but are all exceptional companies well worth a follow.

We tried to pick companies across the size spectrum from cutting edge startups to established brands.

We selected these startups and companies for exceptional performance in one of these categories:

  • Innovation
    • Innovative ideas
    • Innovative route to market
    • Innovative product
  • Growth
    • Exceptional growth
    • Exceptional growth strategy
  • Management
  • Societal impact

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Top Minnesota Health Care Startups

Data sourced from Crunchbase and SemRush.

Medtronic

Medtronic

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Medtronic develops and manufactures medical device technologies and therapies to treat chronic diseases worldwide.

Mayo Clinic

Mayo Clinic

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MayoClinic is a nonprofit medical practice and medical research group focused on integrated health care, education, and research.

Mayo Clinic

Bright HealthCare

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Bright HealthCare develops a health insurance service platform designed to deliver a quality healthcare experience.

Mayo Clinic

Miromatrix Medical

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Miromatrix Medical is engaged in the development of fully biological human organs and organ-derived biological products.

Mayo Clinic

CVRx

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CVRx is a medical device company developing implantable technology for the treatment of high blood pressure.

Mayo Clinic

Rae Wellness

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Rae Wellness is a wellness startup that offers a variety of vegan, non-GMO, and gluten-free supplements.

Mayo Clinic

Bind On-Demand Health Insurance

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Bind administers health insurance for self-funded customers. Bind is health insurance rewired for our on-demand world

Mayo Clinic

Gravie

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Gravie specializes in the fields of health insurance, health care, and employer benefits.

Mayo Clinic

Nice Healthcare

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Nice Healthcare brings healthcare services into the patient’s home using a combination of in-person and virtual visits.

Mayo Clinic

Inspire Medical Systems

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Inspire Medical Systems develops implantable therapeutic devices for the treatment of obstructive sleep apnea.

Mayo Clinic

Predictive Oncology

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Predictive Oncology is working with the pharmaceutical, diagnostic, and biotech industries to develop customizable assessment methods.

Mayo Clinic

ABILITY Network

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ABILITY Network offers CMS-approved, secure Medicare and all-payer online access for claims processing and reimbursement.

Mayo Clinic

Zipnosis

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Zipnosis is a hospital and healthcare company that specializes in online diagnosis and triage, telehealth, and virtual care.

Mayo Clinic

HistoSonics

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HistoSonics specializes in developing medical devices, interventional radiology, and surgical robotics.

Mayo Clinic

BetterYou

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BetterYou is a digital wellness platform that helps to make better health and wellness decisions every day.

Mayo Clinic

Vireo Health

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Vireo Health is a physician-led company dedicated to providing patients with best-in-class cannabis-based products and high quality care

Mayo Clinic

Player’s Health

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Player’s Health is an insurance agency that protects athletes and sports organizations with a unique risk management platform.

Mayo Clinic

Monteris Medical

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Monteris Medical is a medical device venture that develops new technologies for the treatment of cancer.

Mayo Clinic

MIVI Neuroscience

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MIVI Neuroscience focuses on developing and commercializing clinical solutions for neurointerventional procedures.

Mayo Clinic

Relievant Medsystems

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Relievant provides patients with low risk therapy that affords the ability to alleviate their back pain.

Mayo Clinic

Nuvaira

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Nuvaira is a new alternative COPD treatment option that specializes in developing devices for treating lung diseases.

Mayo Clinic

Panbela Therapeutics

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Panbela Therapeutics develops small molecule pharmaceuticals for the oncology and acute care markets.

Mayo Clinic

Calyxt

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Calyxt is an Agbiotech company focused on developing crops with healthier characteristics

Mayo Clinic

Recombinetics

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Recombinetics targets biomedical and regenerative medicine, opening vast new opportunities to improve and extend human life.

Mayo Clinic

Respicardia

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Respicardia develops implantable therapies to improve respiratory and cardiovascular health.

Mayo Clinic

HealthPartners

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HealthPartners is a nonprofit health care provider and health insurance company providing health care services and health plan financing.

Mayo Clinic

ANI Pharmaceuticals

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ANI Pharmaceuticals manufactures oral solid dose products, as well as liquids and topicals.

Mayo Clinic

Datica

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Datica brings the cloud to healthcare and helps highly regulated industries.

Mayo Clinic

Central Logic

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Central Logic is a provider of innovative transfer center and bed management solutions in the healthcare industry.

Mayo Clinic

UnitedHealth Group

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UnitedHealth Group is a healthcare company that offers insurance products and services for everyone.

Mayo Clinic

EnteroMedics

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EnteroMedics® Inc. (NASDAQ: ETRM) is the developer of in-class weight loss treatments for obesity and obesity related risk factors.

Mayo Clinic

Emerging Therapy Solutions

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Emerging Therapy Solutions is an insurance company that specializes in full management of gene and cell therapy for payers.

Mayo Clinic

NeoChord

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NeoChord is a medical device company that develops devices that allow mitral valve repair to be performed on a beating heart.

Mayo Clinic

NovuHealth

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NovuHealth is the leading healthcare consumer engagement company.

Mayo Clinic

4C Medical Technologies

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4C Medical Technologies is a medical device company that develops minimally invasive therapies for structural heart disease.

Mayo Clinic

Hidrate

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Hidrate is an online community creating a smart water bottle that tracks users’ hydration over time and syncs with their phones.

Mayo Clinic

Ativa Medical

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Ativa Medical is working to make diagnostic test results available in moments, rather than hours and days.

Mayo Clinic

Aria CV

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Aria CV is developing a medical device designed to improve the lives of patients living with the disease of pulmonary hypertension.

Mayo Clinic

Learn to Live

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Learn to Live provides an online CBT-based programs to address psychological problems such as depression, stress, anxiety, and others.

Mayo Clinic

Antares Pharma

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Antares Pharma is a revenue-generating product focused specialty pharmaceutical company

Mayo Clinic

Lifesprk

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Lifesprk is a hospital & health care company that offers home care management and senior living services.

Mayo Clinic

Rebiotix

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Rebiotix is a development-stage biotechnology company focusing on the treatment of GI diseases by developing human microbiome.

Mayo Clinic

NxThera

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NxThera develops medical technologies to treat a variety of endourology conditions, including BPH.

Mayo Clinic

Cardiovascular Systems

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Cardiovascular Systems develops and markets medical devices for the treatment of cardiovascular disease.

Mayo Clinic

Ambient Clinical Analytics

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Ambient Clinical Analytics is a provider of clinical analytics solutions to health systems and hospitals,

Mayo Clinic

Entellus Medical

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Entellus Medical develops technology-based treatment solutions for ENT physicians, their patients and payers.

Mayo Clinic

CHF Solutions

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CHF Solutions is a medical device company that focuses on innovative cardiac assist therapy to treat patients.

Mayo Clinic

Pops Diabetes Care

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Pops Diabetes Care offers a virtual healthcare platform to enable people to self-manage diabetes through consumer-centric sensors.

Mayo Clinic

Omcare

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Omcare is a digital health company that enables remote care and medication adherence.

Mayo Clinic

Joshin

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Joshin offers a disability care app that connects individuals to a network of experienced and screened caregivers.

Mayo Clinic

RedBrick Health

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RedBrick Health, a health engagement and behavior-based technology company, helps organizations optimize their health and wellness programs.

Mayo Clinic

Silk Technologies

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SILKTECH focuses on innovating and developing silk-derived protein (SDP) products for ophthalmic applications

Mayo Clinic

Celcuity

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Celcuity transform care for patients with cancer or autoimmune disease.

Mayo Clinic

Abilitech Medical

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Abilitech Medical is a medical device company providing solutions for patients with neuromuscular conditions.

Mayo Clinic

Minnetronix

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We are a medical technology and innovation company with deep expertise in electronic and electromechanical devices.

Mayo Clinic

Healthsense

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Healthsense is a provider of aging services technology, offering technology-enabled care solutions for the senior care continuum.

Mayo Clinic

Mednet

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Clinical Trial Management Solutions

Mayo Clinic

Netgain Technology

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Netgain’s mission is to improve the patient experience by managing the IT operations of healthcare providers nationwide.

Mayo Clinic

ABS

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ABS designs and develops minimally-invasive technology that focuses on relieving pain in the knee.

Mayo Clinic

OneOme

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OneOme is a collaborative concern between the business builder .

Mayo Clinic

Urotronic

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A Minnesota based, medical device company, making an exciting innovation in urethral stricture treatment.

Mayo Clinic

ShiraTronics

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ShiraTronics is in the early stages of developing new innovative therapies to combat debilitating migraine headache.

Mayo Clinic

Tactile Medical

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Tactile Medical develops medical devices that support the treatment of edema and vascular diseases at home.

Mayo Clinic

IMRIS Inc.

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IMRIS provides an image-guided therapy environment, facilitating timely information to clinicians to use during surgical procedures.

Mayo Clinic

Neuroone Medical Technologies

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NeuroOne is a medical technology company focused on improving surgical care for patients suffering from neurological disorders.

Mayo Clinic

Osprey Medical

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Osprey Medical develops and commercializes its propriety CINCOR™ System designed for the prevention of contrast induced mephropathy.

Mayo Clinic

Cardionomic

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Cardionomic is a medical device developer that treats reduced cardiac output.

Mayo Clinic

Apothecary Products

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Apothecary Products has been the Pharmacist’s partner, providing a full line of quality pharmacy supplies and home healthcare products.

Mayo Clinic

GeneMatters

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GeneMatters delivers genetic counseling services for hospitals, health networks, academic research centers, and genetic testing labs.

Mayo Clinic

Branch Basics

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Branch Basics is to revolutionize the health of homes by helping people remove harmful chemicals from their daily lives.

Mayo Clinic

Rotation Medical

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Rotation Medical develops treatments for rotator cuff disease by reversing disease progression and restoring long-term shoulder function.

Mayo Clinic

Spineology

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Spineology provides anatomy-conserving spine surgery technology solutions.

Mayo Clinic

Metavention

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Metavention develops medical devices to help with interventional therapies for Type 2 diabetes.

Mayo Clinic

Sansoro Health

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Sansoro Health is a healthcare information technology company

Mayo Clinic

Torax Medical

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Torax Medical develops an implantable device for the treatment of gastroesophageal reflux disease.

Mayo Clinic

Cogentix Medical

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Cogentix Medical products have increased treatment efficiency and lowered patient risk.

Mayo Clinic

Marani

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Prenatal Care Solutions

Mayo Clinic

Zyga Technology

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Zyga Technology is a surgical solutions provider developing & commercializing medical devices for treating spine problems.

Mayo Clinic

Imricor Medical Systems

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Imricor Medical Systems develops magnetic resonance imaging compatible electrophysiology tools for the treatment of cardiac arrhythmias.

Mayo Clinic

Venture Med Group

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VMG designs, develops which enable interventionalists to cost effectively treat peripheral artery diseases.

Mayo Clinic

ValenTx

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ValenTx is a development-stage medical device company that focuses on minimally-invasive methods for the treatment of morbid obesity.

Mayo Clinic

Cryosa

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CryOSA is a medical device company developing novel treatments for obstructive sleep apnea.

Mayo Clinic

Treatment.com

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Treatment.com is a healthcare technology startup that uses AI to improve health through personalized recommendations and insights.

Mayo Clinic

SupDoc

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Virtual access to local doctors

Mayo Clinic

Murata Vios

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Murata Vios is a medical technology company developing wireless monitoring platform for intensive healthcare applications.

Mayo Clinic

Luminary Therapeutics

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Luminary Therapeutic is a cancer research center that develops pre-clinical stage cell therapy for cancer and autoimmune diseases.

Mayo Clinic

Mardil Medical

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Mardil Medical is a medical device company developing therapies for structural heart diseases and heart abnormalities.

Mayo Clinic

NightWare

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NightWare is a digital therapeutic platform that helps people suffering from traumatic nightmares to get a more restful night’s sleep.

Mayo Clinic

The Big Know

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The Big Know delivers video courses and podcasts taught by renowned experts.

Mayo Clinic

Interrad Medical

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Interrad Medical develops innovative medical devices for use in minimally invasive interventional and surgical procedures.

Mayo Clinic

Clinician Nexus

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Collaborative Clinical Education Management

Mayo Clinic

MicroOptx

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MicroOptx is an early-stage medical device company that leverages academic bioengineering.

Mayo Clinic

Optum

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OptumInsight provides analytics, technology, and consulting services to improve the performance of health systems.

Mayo Clinic

Sonex Health

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To be the World Leader in ultrasound-guided surgery

Mayo Clinic

Boka

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Modern oral care powered by nature + science.

Mayo Clinic

Prevent Biometrics

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Prevent’s patented technology was developed at Cleveland Clinic by top neurosurgeons

Mayo Clinic

Preceptis Medical

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Preceptis Medical develops surgical tools that allow ear tube procedures to be performed with less pain.

Mayo Clinic

Cardio Flow

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Cardio Flow is an early-stage development company with a new approach to orbital atherectomy.

Mayo Clinic

Elucent Medical

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Elucent Medical is a new idea in breast cancer treatment that exists to bring better healthcare ideas.

Mayo Clinic

Leafline Labs

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LeafLine Labs provides high quality medical cannabis and care to patients.

Mayo Clinic

LogicStream Health

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LogicStream Health provides Hospitals and Health Systems with Strategic Clinical Decision Support Management Solutions.

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