Top San Francisco Healthcare Startups Revolutionizing American Medical Industry

January 29, 2024

When it comes to innovation in the healthcare industry, the city by the Bay leads the charge. San Francisco’s rich history as a hub for tech startups combined with access to world-class healthcare institutions makes it the ideal breeding ground for health-focused enterprises. This article shines a spotlight on some of San Francisco’s leading healthcare startups established in 2020 and beyond. From mental health to fertility and biotechnology, these companies are pushing the boundaries of what’s possible in health care.

We’ve compiled a list of companies that are not only leading in innovation but also challenging the status quo in healthcare delivery, each with its unique value proposition. These startups provide an array of services from telehealth platforms and AI-based tools for patient care to developing therapeutics for age-related disorders.

Without further adieu, let’s take a closer look at these trail-blazing health care startups from San Francisco, founded in 2020 and beyond.


Transcarent, co-founded by Glen Tullman, is a consumer-directed health and care platform for employees of self-insured employers and their families. They leverage software, technology, health guides, and data science to support consumers with unbiased information, trusted guidance, and access to high-value care. Connect with them on LinkedIn and Twitter @transcarent.


Founded by Jimmy Qian and Lucia Huang, Osmind is advancing new evidence-based medicine to help people living with moderate to severe mental health conditions. Learn more about Osmind through their LinkedIn, @OsmindHQ and their Facebook page.

Teal Health

Pioneered by Kara Egan, Teal Health aims to transform women’s health, particularly cervical cancer screening, with their FDA-approved self-collection kit and telehealth platform. Follow Teal Health on LinkedIn and Twitter @tealhealth.

Little Otter

Helmed by Helen Egger and Rebecca Egger, Little Otter offers a family-focused mental health service for children through their innovative app. Learn more about Little Otter on their LinkedIn, @LittleOtterCare and their Facebook page.

Prolific Machines

Co-founded by Declan Jones, Deniz Kent, Max Huisman and Victor Jones, Prolific Machines is a biotech start-up driving cell production technologies to contribute towards a sustainable and healthy future. Connect with them on LinkedIn.


Founded by Nicholas Macario and Vivekanand Rajkumar, Verifiable develops an API enabling healthcare providers to simplify license authentication through real-time connection to state and federal databases. Catch up with Verifiable on @verifiable and their LinkedIn page.


Alife, founded by Paxton Maeder-York, uses artificial intelligence to help physicians increase a patient’s chances of pregnancy success. Learn more about Alife on their LinkedIn, Twitter @alifeivf and their Facebook page.


Founded by Andrew Brackin and Simon Burns, Vial, a contract research organization, is redefining clinical trials to provide faster, more efficient results at lower costs. You can get in touch with Vial on their LinkedIn, @vialtrials and their Facebook page.

Aware Healthcare

Aware Healthcare, founded by AJ Goldstein, leverages their data platform to deliver high-quality science-driven mental health care. Check out Aware Healthcare on their LinkedIn page.

TenSixteen Bio

TenSixteen Bio, co-founded by Mark Chao and Pradeep Natarajan, is a biotechnology enterprise using somatic mosaicism and clonal hematopoiesis to develop treatments for age-related disorders.


Sunnyside, under the leadership of Ian Andersen and Nick Allen, has developed an alcohol tracking app that supports users in building healthier drinking habits. You can connect with Sunnyside through their, @joinsunnyside, LinkedIn and Facebook page.

In the wake of COVID-19, these startups are proving that innovative solutions for healthcare can emerge from adversity. Through combining vision, innovative technology and exceptional leadership, these companies are ones to watch as they work to improve and save lives and create a healthier future for all.

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